Abstract: The main-lobe interrupted sampling repeater jamming is a kind of coherent jamming. This jamming is injected into the radar from the main lobe of the antenna, which will seriously degrade the performance of the radar. In this paper, for the distributed radar system with single transmitter and multiple receivers, a mathematical model containing the target signal and interrupted sampling repeater jamming is established. Moreover, an anti-jamming method based on minimum variance distortionless response (MVDR) is proposed. The pure interference covariance matrix is estimated by jamming recognition. The time-frequency analysis is performed on the one-dimensional range profile, and the target and the jamming can be identified according to their time-frequency characteristics. After this, the pure interference information is estimated as the training data of MVDR beamformer, suppressing the interrupted sampling repeater jamming. Finally, the simulation results are given to demonstrate the effectiveness of our method.