Abstract: According to the problem that quality of service is difficult to guaranteed for Multi-class mixed transmission in wireless sensor network，we put forward a kind of protocol，named DSMQR(Differentiated Services Multipath QoS Routing Protocol). The model of sensor node communication is designed by the idea of cross-layer collaborative and the service framework is established with collaborating the network layer and MAC layer. The distribution model is adopted a data-centric scheduling of multi-priorities queue. The business flow routing path is selected by value of comprehensive cost function. The simulations show that DSMQR is satisfied of QoS requirements for the timeless of delay sensitive packet and reliability of reliability sensitive packets ，which effective optimized system resources.