Abstract: With the densification of the future-generation mobile networks, how to manage interference efficiently with coarse channel information is a critical and challenging task. In this paper, we propose transmission strategy to coordinate inter-cell interference with topological information for multi-cell multi-user networks with multiple antennas and single antennas. To resolve the scheduling conflict between users in different cells, we unify user scheduling and interference management, and introduce the potential conflict graph based on the unified model. By using the topological interference management on this graph, the optimal transmission strategy that minimizes the transmission resource is obtained. Simulation results show that the proposed transmission strategy significantly boosts both the average rate per user and the cell edge user’s rate compared with the traditional method, which first selects users and then coordinates the inter-cell interference.