Abstract: Aimed at the high complexity problem of the single-channel co-frequency signals blind separation in non-cooperative communication, this paper based on the serial interference cancellation(SIC) algorithm, constructed single-channel co-frequency signals’ Channel receiver model, proposed a low complexity blind separation algorithm based on SIC, and processed the channel truncation in channel reconstruction, avoid the loss of separation performance. The simulation experiments show that the algorithm has similar performance with existing algorithms, but its complexity is reduced by two-thirds, and it is not sensitive to the frequency offset.