Abstract: In order to further improve the Femtocell network spectrum utilization and optimize power allocation, in orthogonal frequency division multiplexing (OFDM) system networks, a subcarrier joint optimization of the multi-users’ resource allocation algorithm is proposed. This algorithm is to maximize the system spectrum efficiency, which is considered as the objective function, jointing the Femtocell selection factor to optimize the standby mode selection of the Femtocell. Furthermore, the algorithm is to allocate the subcarrier equally and finally use a linear capped water-filling algorithm to optimize the allocation of the Femtocell users’ power. The simulation results show that multi-users’ resource allocation algorithm not only improves the spectrum and power utilization significantly, but also increases the system throughput and users’ fairness. The Femtocell resource optimization model can effectively improve the shortage of spectrum and the waste of power, and reduce the interference of Femtocell.