Abstract: Orbital angular momentum (OAM) as a carrier of quantum information, can be applied to the measurement device-independent quantum key distribution protocols (MDI-QKD), to eliminate the basis-dependent flaw. Decoy state used in quantum key distribution can eliminate photon splitting attack when the protocol uses weak coherent source. In this paper, an OAM-MDI-QKD protocol was proposed, which could avoid the basis-dependent flaw, and increased the key generation rate. The key generation of the decoy-state OAM-MDI-QKD scheme using infinite decoy state and two decoy state was deduced. The results show that the key rate of the proposed OAM-MDI-QKD protocol is higher than that using polarized state.