Abstract: The fourth-order cumulant 2-D slice is one of the important parameter estimation methods for spread spectrum communication systems，even in low signal-to-noise ratio environment. This paper apply the fourth-order cumulant 2-D slice to DS-SS/BPSK signal parameter estimation. Meanwhile, we study the effect of estimator parameters, including detection window size, symbol duration and accumlation times, on the estimation performance. We analyze the effect of these parameters with control variable method, and the simulation results prove our analysis. According to the analysis and simulation result, the lower symbol duration to spreading code period ratio can help anti-estimator reduce the detection probability. On the other hand, the larger detection window size and accumation times can help the estimator to achieve better performance. Thus, it’s important to study the effect of these parameters on estimation performance of the forth-order cumulant 2-D slice.