Abstract: To research the electronic nose performance affected by the nasal cavity structure of electronic nose and the arrangement of sensor array, by using the Fluent module in ANSYS Workbench, this paper made the numerical simulation of fluid characteristics during the gas transferred in different nasal cavity structure. The paper analyzed the odor concentration distribution in the sensor sensitive element when it was in different nasal cavity structure and in different location of sensor array. Then the paper discussed the ways how to increase the odor concentration in the sensor sensitive element, so as to improve the olfaction ability of electronic nose. The results indicate that both the nasal cavity structure and the sensor location have the influence on the olfaction ability of electronic nose. The results also indicate that the method which using ANSYS to make the optimization design for the nasal cavity structure of electronic nose is effective and feasible.