Abstract: ‍ ‍Audio processing localization based on Head-related transfer function is the key technology of spatial audio rendering at present. Head-related transfer function is greatly influenced by individual differences， but due to its high measurement cost， non-individual head-related transfer function is often used in practical applications. Regarding the role of individual head-related transfer function， under different experimental conditions， the conclusions given by different researchers are different. This paper summarizes the research on three main aspects of its localization performance： increasing the horizontal and vertical localization accuracy； reducing the inside-the-head localization effect； reducing the front-to-back confusion phenomenon. By analyzing the acoustic principles of individual head-related transfer function to enhance the sense of hearing， and comprehensively examining the existing subjective experimental results， this paper shows that the use of individual head-related transfer function for spatial audio rendering is helpful to improve the sense of immersion， and it shows different performances for different localization attributes.