Abstract: Image acquisition is the key step in the LCD Mura detection system, but the large data of high-definition screen image may bring severe pressure on the detection system in real-time data acquisition, transmission and processing. To solve this problem, a compressive sensing method is proposed by applying the compressive sampling first in row and then in column. And an implementation of compressive sensing circuit for LCD Mura image is also presented, it consists of compressive sampling module, control unit and image transpose RAM, etc. This method takes a full consideration of the whole image sparsity, making it a more effective way of image compressive sampling. The structure of the circuit is simple and easy to implement. Experiments on FPGA show the effectiveness and efficiency of the proposed method.