Abstract: The phenomenon of cross frequency coupling in brain signal is closely related to human conscious activity. We investigate the effect of different hand movement on the cross frequency coupling characteristic in MEG, combining refined frequency bands with various cross frequency coupling measurements. Firstly, we consider a refined frequency bands scheme for MEG signals and three cross frequency coupling methods with the primary and secondary relationship, and compare the statistical results with two kind of frequency band coupling modes, i.e. high frequency versus low frequency, or conversely. Furthermore, we take advantage of the frequency band coupling connection in different channels and the concept of stimulation and response of the source frequency bands, and use the coherence measurement to investigate the statistical results of the above two coupling modes, in order to obtain the appropriate source frequency bands, the stimulation channels and the response channels. The results show we can more effectively distinguish between different MEG signals of various wrist  movement.